Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Hypoxia-induced exosomes involved in cancer biology

From: Role of hypoxia-induced exosomes in tumor biology

Regulatory factors Cancer types Response to hypoxia Biological function Mechanism Ref
Exosomal miR-135b Multiple myeloma Increased Increase angiogenesis Downregulates its target FIH-1 [37]
Exosomal miR-23a Lung cancer Increased Increase angiogenesis and migration Inhibition of PHD1, PHD2 and ZO-1 [44]
Exosomal miR-210 Leukemia Increased Increase angiogenesis Inhibits the expression of Ephrin A3 [45]
Exosomal miR-494 Non-small cell lung cancer Increased Increase angiogenesis Downregulates PTEN and activates Akt/eNOS pathway in ECs [46]
Exosomal miR-21 Oral squamous cell carcinoma Increased Promote migration and invasion Downregulate a pool of genes and induces EMT of these cells. [56]
Exosomal miR-940 Epithelial ovarian cancer Increased Regulate immune response Induces macrophages to express higher levels of the M2-type markers CD163 and CD206 [70]
Exosomal miR24-3p Nasopharyngeal carcinoma Increased Regulate immune response Not mentioned [71]
Exosomal miR-210 Hypoxic cancer Increased Increase angiogenesis Inhibits the expression of Ephrin A3 and PTP1B [72]
Exosomal linc-UCA1 Bladder cancer Increased Promote migration and invasion Promotes EMT [55]
Exosomal linc-RoR Hepatocellular cancer Increased Promote migration and invasion Not mentioned [73]
Exosomal proteins Prostate cancer Increased Promote migration and invasion Not mentioned [54]
Exosomal CA9 Renal cell carcinoma Increased Increase angiogenesis Upregulates its target MMP2 [74]
Exosomal TF Glioblastoma multiforme Increased Increase angiogenesis Enhances TF/VIIa-mediated PAR-2 activation and activates endothelial cells [75]
Exosomal Wnt4 Colorectal cancer Increased Increase angiogenesis Increases β-catenin nuclear translocation in endothelial cells [76]
Exosomal MMP13 Nasopharyngeal carcinoma Increased Promote migration and invasion Not mentioned [77]
Exosomal HIF1α Nasopharyngeal carcinoma Increased Promote migration and invasion Promotes EMT [78]
Exosomal TGF-β1 and miR23a Hypoxic cancer Increased Regulate immune response TGF-β1 downregulates NKG2D and miR23a directly targets CD107a [79]