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Fig. 2 | Molecular Cancer

Fig. 2

From: LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression

Fig. 2

Knockdown of lncRNA PTAR inhibits tumor progression in an orthotopic mouse model of OvCa. a The macroscopic observation of the size and range of metastatic lesions in nude mice. b Representative images of tumors from nude mice bearing xenograft tumors with SKOV3 cells infected with a lentivirus carrying a short hairpin RNA against PTAR (lenti-sh-PTAR) or its scramble negative control (lenti-sh-Scramble). c, d The average number of metastatic nodules and tumor xenograft weights in nude mice. n = 11–13. *P < 0.05. e An immunohistochemistry assay was applied to determine the expression of E-cadherin, fibronectin 1 (FN1), zinc finger E-box binding homeobox 1 (ZEB1) and vimentin in a cell-derived xenograft tumor model. f, g The expression of epithelial-mesenchymal transition (EMT) relevant markers, including E-cadherin, vimentin, FN1 and ZEB1 in tissues derived from xenograft tumors, as determined by qRT-PCR and western blot, respectively. n = 6. *P < 0.05

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Molecular Cancer

ISSN: 1476-4598