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Fig. 3 | Molecular Cancer

Fig. 3

From: LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression

Fig. 3

PTAR promotes EMT and metastasis through the modulation of miR-101/ZEB1. The SKOV3, A2780 and OVCAR3 cells were transfected with PTAR plasmid with or without miR-101 mimic. a, b Wound healing assays showing cell migration in SKOV3 and A2780 cells. n = 4, *P < 0.05 vs. pcDNA3.1, #P < 0.05 vs. PTAR. c, d Migration assays in SKOV3 and A2780 cells, respectively. e The invasiveness of SKOV3 cells was determined by an invasion assay using matrigel transwell chambers. n = 4, **p < 0.01. f The protein levels of E-cadherin, vimentin, FN1 and ZEB1 in SKOV3 cells. n = 5, *P < 0.05 vs. pcDNA3.1, #P < 0.05 vs. PTAR. g The protein levels of E-cadherin, vimentin, FN1 and ZEB1 in A2780 cells. n = 5, *P < 0.05 vs. pcDNA3.1, #P < 0.05 vs. PTAR. h The protein levels of E-cadherin and ZEB1 in OVCAR3 cells. n = 3, *P < 0.05 vs. pcDNA3.1, #P < 0.05 vs. PTAR

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