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Fig. 7 | Molecular Cancer

Fig. 7

From: The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment

Fig. 7

Up-regulated miR-548k expression levels predict aggressive clinicopathological characteristics and a poor prognosis in ESCC patients. a, Representative miRNA ISH photos of miR-548k expression and EGFR, KLF10 IHC images in the same ESCC samples. Scale bar: 100 μm. b, Representative miRNA ISH photos of miR-548k expression and ADAMTS1 IHC images in the same ESCC samples. Scale bar: 100 μm. c, Kaplan–Meier survival analysis (log-rank test) and multivariate Cox analysis of all ESCC patients stratified by different clasifiers as indicated. d, The abundance of miR-548k in serum of early ESCC patients and health people were detected by real time PCR. Relative expression level were normalized to U6. e, ROC curve evaluated the diagnostic accuracy of miR-548k abundance. ROC, receiver operator characteristic. AUC, area under the curve. f, MiR-548k abundance in the serum of ESCC patients with or without lymph node metastasis. g, MiR-548k abundance in the serum of ESCC patients with different grade of differentiation. ***p < 0.001. **p < 0.01. ns, no significant

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