Table 1 Correlation of SPAG5 expression and clinical features of HCC patients
Variable | SPAG5 | |||
|---|---|---|---|---|
All cases | Low expression | High expression | P valuea | |
Age (years) b | 0.524 | |||
< 49 | 143 | 68 (47.6%) | 75 (52.4%) | |
≥ 49 | 155 | 68 (43.9%) | 87 (56.1%) | |
Gender | ||||
Male | 272 | 125 (46.0%) | 147 (54.0%) | 0.721 |
Female | 26 | 11 (42.3%) | 15 (57.7%) | |
HBV | 0.858 | |||
Positive | 238 | 108 (45.4%) | 130 (54.6%) | |
Negative | 60 | 28 (46.7%) | 32 (53.3%) | |
AFP (ng/ml) | 0.933 | |||
< 20 | 76 | 35 (46.1%) | 41 (53.9%) | |
≥ 20 | 222 | 101 (45.5%) | 121 (54.5%) | |
Cirrhosis | 0.101 | |||
Yes | 264 | 116 (43.9%) | 148 (56.1%) | |
No | 34 | 20 (58.8%) | 14 (41.2%) | |
Tumor size (cm) | 0.039 | |||
< 5 | 67 | 38 (56.7%) | 29 (43.3%) | |
≥ 5 | 231 | 98 (42.4%) | 133 (57.6%) | |
Tumor multiplicity | 0.058 | |||
Single | 182 | 91 (50.0%) | 91 (50.0%) | |
Multiple | 116 | 45 (38.8%) | 71 (61.2%) | |
Differentiation | 0.034 | |||
Well-Moderate | 219 | 108 (49.3%) | 111 (50.7%) | |
Poor-undifferentiated | 79 | 28 (35.4%) | 51 (64.6%) | |
Vascular invasion | 0.008 | |||
Yes | 62 | 19 (30.6%) | 43 (69.4%) | |
No | 236 | 117 (49.6%) | 119 (50.4%) | |
LNM | 0.034 | |||
Yes | 24 | 6 (25.0%) | 18 (75.0%) | |
No | 274 | 130 (47.4%) | 144 (52.6%) | |
Tumor capsule | 0.391 | |||
Absent | 181 | 79 (43.6%) | 102 (56.4%) | |
Present | 117 | 57 (48.7%) | 60 (51.3%) | |
TNM | 0.045 | |||
I-II | 152 | 78 (51.3%) | 74 (48.7%) | |
III-IV | 146 | 58 (39.7%) | 88 (60.3%) | |