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Table 1 summary of the expression and signaling pathways of circRNAs involved in cancer

From: Emerging function and potential diagnostic value of circular RNAs in cancer

Cancer type CircRNA Funtion Expression in tumors References
Lung adenocarcinoma hsa_circ_0012673 promotes LAC cell proliferation and tumor growth by decoying miR-22 Up [42]
hsa_circ_0013958 promotes cell proliferation, migration and invasion by sponging miR-134 Up [57]
circPRKC1 positively correlated with tumor size and TNM stage, promotes cell proliferation and migration by regulating miR-545/589 Up [6]
circRNA_102231 associated with the advanced TNM stage, lymph node metastasis and poor overall survival, promotes cell proliferation and invasion ability Up [58]
has_circ_0007385 promotes the proliferation activity, colony-forming ability, migration and invasion of NSCLC cells in vitro and the tumor growth in vivo by decoying miR-181 Up [59]
circ0006916 inhibits cell proliferation by regulating cell cycle progression Down [60]
f-circEA promotes cell migration and invasion Up [7]
circFARSA promotes cell migration and invasion by sponging miR-330-5p and miR-326 Up [63]
hsa_circRNA_103809 promotes cell proliferation and invasion in vitro and tumor growth in vivo by sponging miR-4302 Up [61]
circFADS2 correlated with advanced TNM stage, lymph node metastasis, poor differentiation and shorter overall survival of NSCLC patients. promotes cell proliferation and invasion ability Up [62]
Colorectal cancer circHIPK3 promotes cell proliferation, and colony-forming ability, migration and invasion by decoying miR-7 invasion by decoying miR-7 Up [8]
circCCDC66 promotes cancer cell proliferation, migration and metastasis in vitro and in vivo by sponging miRNA-33b and miR-93 Up [9]
ciRS-7 positively correlated with advanced tumor stage, tumor depth and metastasis by downregulating miR-7 UP [64]
circBANP related with cell proliferation and colony formation ability Up [65]
hsa_circ_0014717 correlated with TNM stage, distal metastasis, and prognosis of CRC patients, antagonizes cell proliferation and colony-forming ability, as well as induces cell cycle arrest at G0/G1 phase Down [66]
Gastric cancer has_cric_0000096 inhibits gastric cancer proliferation and migration by suppressing cyclin D1, CDK6, MMP-2 and MMP-9 Down [68]
circPVT1 promotes cell proliferation by sponging miR-125 Up [11]
circLARP4 Impairs GC cell proliferation and invasion, associated with tumor size, lymphatic metastasis and the therapeutic outcomes of GC patients by regulating miR-424 Down [10]
Pancreatic cancer hsa_circ_0000977 associated with poor prognosis in PDAC patients, promotes cell proliferation and colony formation ability by sponging hsa-miR-874-3p Up [43]
circ-LDLRAD3 associated with venous invasion, lymphatic invasion and metastasis Up [70]
circPDE8A correlated with lymphatic invasion, T factor and TNM stage, promotes migration or invasion, cell proliferation and EMT Up [71]
Hepatocellular carcinoma circMTO1 correlates with the poor survival of patients, inhibits cell proliferation and invasion by decoying miR-9 Down [13]
circARSP91 AR suppresses circARSP91expression by upregulating the expression of ADAR1 Down [14]
cSMARCA5 correlated with advanced tumor stage, tumor size and the presence of microvascular invasion through sponging miR-17-3p an miR-181b-5p Down [15]
circ_0067934 promotes cell proliferation and metastasis in vitro and in vivo by regulating miR-1324 Up [72]
circRNA_100,338 correlated with decreased cumulative survival rate, increased vascular invasion and lung metastasis in HCC patients by suppressing miR-141-3p Up [73]
circHIPK3 promotes the proliferation and migration of HCC cells, as well as xenograft tumor growth in vivo by downregulating miR-124 Up [12]
circC3P1 represses the migration and invasion of HCC cells in vitro, and inhibits HCC cells proliferation and lymphatic metastasis in vivo by sponging miR-4641 Down [74]
Breast cancer circGFRA1 correlated with tumor size, TNM staging, lymph node metastasis and histological grade, promotes cell proliferation and the colony-forming ability by decoying miR-34a Up [16]
circAmotl1 increases invasive capacity, reduces number of apoptosis cells, and augmentes tumor-forming capacity by promoting c-myc nucleus-translocation Up [17]
circRNA-000911 suppresses the invasive capacity and proliferation, reduces colony formation ability and elevates the proportion of apoptotic cells by sponging miR-449a Down [75]
cricABCB10 promotes cell proliferation and colony formation capacity by downregulating miR-1271 Up [76]
hsa_circ_0011946 correlated with RFC3 expression, promotes migration and invasion of MCF-7 cell Up [77]
Bladder cancer circ-ITCH suppresses cell proliferation, migration and invasion in vitro, as well as tumorigenesis in vivo, through sponging miR-17 and miR-224 Down [44]
circRNA-MYLK increases the tumorigenicity of BC cells, distinct metastatic lesions in mice lungs and tumor microvessels by decoying miR-29a/ Up [79]
circHIPK3 suppresses the aggressiveness and metastasis of bladder cancer cells in vitro and in vivo by targeting miR-558 Down [80]
Cdr1as inhibits the migration and invasion capabilities, as well as induces cell cycle arrest Down [81]
Glioblastoma circ-FBXW7 associated with glioblastoma patient overall survival, inhibits proliferation and cell cycle acceleration by encoding FBXW7-185aa Down [51]
circSHPRH encodes SHPRH-146aa which can protect SHPRH and reduce proliferation and the malignant phenotype Down [52]
circ-SHKBP1 promotes the viability, migration and tube formation of glioma-exposed endothelial cells by sponging miR-544a or miR-379 Up [45]
cric-TTBK2 promotes cell proliferation, migration and invasion, but inhibits the apoptosis of glioma cells by regulating miR-217 Up [82]
Other cancers
Oral squamous cell carcinomas circRNA_100290 promotes cell proliferation in vitro and the growth of tumors in vivo by decoying miR-29b Up [46]
circDOCK1 inhibits cell apoptosis by sponging miR-196a-5p Up [83]
Osteosarcoma cricUBAP2 correlated with tumor stages, promotes cell proliferation in vitro and cell growth in vivo by downregulating miR-143 Up [47]
circ-NT5C2 correlated with tumor volume and weight in a mice model, promotes cell proliferation and invasion in vitro by decoying miR-448 Up [84]
circRNA_0009910 promotes cell proliferation and inhibits apoptosis by sponging miR-449a/IL6R Up [85]
has_circ_0001564 promotes cell viability and the colony formation vitality by decoying miR-29c-3p Up [87]
circNASP promotes the proliferation and invasion of OS cells by sponging miR-1253 Up [86]
Hematological tumors f-circM9, f-circPR contributes to cellular transformation, and promotes cell viability and resistance upon therapy Up [54]