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Table 2 Circular RNAs as plasma biomarker in cancer

From: Emerging function and potential diagnostic value of circular RNAs in cancer

circRNA Cancer type Expression in plasma Clinical correlation ROC curve References
AUC sensitivity Specifity
Hsa_circ_0013958 LAC up TNM stage, lymphatic metastasis 0.815 0.755 0.796 [57]
F-circEA NSCLC up [7]
Hsa_circ_000745 GC down tumor differentiation 0.775 0.800 0.633 [93]
Hsa_circ_0001017 /hsa_circ_0061276 GC Down distal metastasis 0.966 0.955 0.957 [94]
Hsa_circ_0000520 GC Down TNM stage, CEA expression 0.8967 0.8235 0.8444 [95]
Hsa_circ_2059 GC Down distal metastasis, TNM stage, gender and age 0.73 [97]
Circ-LDLRAD3 Pancreatic cancer Up venous invasion, lymphatic invasion 0.87 0.8033 0.9355 [70]
CircPVT1 OS Up advanced Enneking stage, chemoresistance, lung metastasis 0.871 [98]
Circ-KLDHC10 CRC Up [99]
Circ-PDE8A PDAC Up duodenal invasion, vascular invasion, T factor or TNM stage [71]