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Fig. 3 | Molecular Cancer

Fig. 3

From: LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1

Fig. 3

ANRIL regulates glucose metabolism through the AdiopR1/AMPK/SIRT1 signaling pathway. a The glucose uptake after the transfection of si-ANRIL and si-AdipoR1 in MOLM-13 and HL-60 cells. b The relative levels of lactate after the transfection of si-ANRIL and si-AdipoR1 in MOLM-13 and HL-60 cells. The protein expression of GLUT1 and LDHA were decreased after the transfection of siRNA against ANRIL (c) and AdipoR1 (d) respectively in AML cells. The protein expression of AMPK, p-AMPK and SIRT1 were significantly decreased after the transfection of siRNA against ANRIL (e) and AdipoR1 (f) respectively in AML cells. g Western blot results shown the protein levels of LDHA, GLUT1, SIRT1, the total AMPK and pAMPK when we overexpressed ANRIL in HL60 cells. h The proposed working model: in normal cells, ANRIL has a lower expression level;While in AML patients, ANRIL was found to be aberrantly highly expressed and acts as an oncogene via regulating cell senescence and glucose metabolism

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Molecular Cancer

ISSN: 1476-4598