Fig. 3

A simplified illustration of YAP/TAZ and fatty acids. (a). SCD1 promotes the synthesis of unsaturated fatty acids. Unsaturated fatty acids activate Wnt ligand. Activation of the Wnt ligand combined with FZD4 receptor to damage the destruction complex, ultimately stabilize β-catenin and YAP/TAZ protein activity and promote β-catenin and YAP/TAZ accumulation in the nucleus to play the function role of transcription regulation. (Destruction complex: APC, Axin1, GSK3, β-TrcP). (b). Free fatty acid induces high expression of JCAD, which in turn binds to the domain of LATS2 kinase and inhibits the ability of LATS2 to phosphorylate YAP, leading to activate YAP transcription by dephosphorylating and promote YAP nuclear translocation to promote hepatoma cell proliferation. (c). Palmitate promotes YAP transcriptional activity in a F-actin-dependent manner. (d). Palmitate attaches to TEAD cysteine residues to palmitoylate TEAD, stabilizes TEAD binding to YAP/TAZ and promotes their transcriptional activity