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Fig. 1 | Molecular Cancer

Fig. 1

From: AR–PDEF pathway promotes tumour proliferation and upregulates MYC-mediated gene transcription by promoting MAD1 degradation in ER-negative breast cancer

Fig. 1

PDEF co-expresses with AR in ER-negative BC tissues. a IHC staining showing the co-expression of AR and PDEF in an AR+ BC specimen and no expression of both AR and PDEF in an AR BC specimen (magnification, × 100 and × 400). b Immunofluorescence staining showing the co-expression of AR and PDEF in an AR+ BC specimen and no expression of both AR and PDEF in an AR BC specimen (magnification, × 100). c PDEF protein expression levels in BC tissues (T) and paired non-tumour tissues (N) were examined by performing western blotting. The non-tumour tissues corresponded to adjacent normal tissues in the same patient. d Kaplan–Meier curves showing the OS (top left, P = 0.040) or RFS (top right, P = 0.031) of patients with PDEF+ vs. PDEF tumours. Kaplan–Meier curves showing the OS (bottom left, P = 0.043) or RFS (bottom right, P = 0.027) of patients with AR+PDEF+ vs. others tumours

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