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Fig. 1 | Molecular Cancer

Fig. 1

From: A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

Fig. 1

Characterisation of resistant melanoma cells. (a) Vemurafenib dose-response analysis in sensitive A375 (black) and resistant A375X1 cells (grey). (b) Growth comparison between untreated sensitive cells versus resistant cells under constant PLX4032 treatment (1 μM). (c) Western blot analysis of A375 and A375X1 in absence or presence of PLX4032 (3 h). Before PLX4032 treatment cells were starved for 16 h. α-Tubulin was used as a loading control; representative blots of three biological replicates are shown. (d) Vulcano plot showing differentially expressed genes in resistant compared to sensitive melanoma cells (FDR < 0.01, at least 1.5-log fold change). (e) Top differentially expressed mRNAs in resistant cells. (f) Western blot analysis detecting ALKRES only in resistant A375X1 cells. α-Tubulin was used as a loading control; representative blots of three biological replicates are shown

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