Fig. 3

The expressions of circ-KIAA1244 GC samples and clinical information analysis. (a) circ-KIAA1244 expression was down-regulated in GC tissues and plasmas compared to normal controls. The correlation of their -ΔCt value was determined. N indicates normal and T indicates tumor. (b) The expression of circ-KIAA1244 in GC cell lines was lower than that in GES-1 significantly. (c) The area under the ROC curve (AUC) in distinguishing GC plasmas and normal ones was 0.7481. (d) Kaplan-Meier overall survival curve revealed patients with lower circ-KIAA1244 expression showed a reduced survival time. (e) There was no significant difference between the expression of circ-KIAA1244 in plasmas and corresponding plasma exosomes. (f) Theoretical model diagram of circ-KIAA1244 in GC: we proposed that GC-tissues-derived circ-KIAA1244 might be transmitted to plasmas via exosomes delivery and could serve as a biomarker in GC.*P<0.05, **P<0.01, ***P<0.001