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Fig. 6 | Molecular Cancer

Fig. 6

From: Proteogenomic characterization and comprehensive integrative genomic analysis of human colorectal cancer liver metastasis

Fig. 6

Somatic coding mutations in paired normal colorectal samples, metastatic CRC and hepatic metastatic focus. a Mutation types in 6 specimens from 2 patients, including 2 sets of PN, primary MT, and synchronous matched LM. T > A transversions were the most common nucleotide substitution. b Distribution of SNVs in exonic, intronic, UTR and splicing regions based on our RNA-sequencing data. c Distribution of indels and non-synonymous SNVs in 6 samples from 2 patients, including 2 sets of PN, primary MT, and synchronous matched LM specimens. d Numbers of MT-specific, LM-specific and MT & LM-shared indels and nonsynonymous SNVs. Mutations involved in CLM including the TLL2A302S mutation, which was identified in both the MT and LM groups (e) and the KLF11D19N mutation, which was specific for the LM cohort (f). Two frequently mutated sites (DMRTB1R202H and PARP4V458I) in the MT cohorts were identified by SNP genotype analysis, with separate mutation rates of 5.26% (2/38) (g) and 17.5% (7/40) (h)

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