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Fig. 2 | Molecular Cancer

Fig. 2

From: Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer

Fig. 2

Changes of gene expression profile and gene set in NSCLC cells upon knockdown of G9a. a Unsupervised hierarchical clustering analysis of global expression profiles in A549 and H1299 cells upon G9a knockdown. The two top rows represent two independent siRNA repeats, C1/2 is for control siRNA and G1/2 is for specific siRNA1/2 for G9a. b qRT–PCR, c Western blot analysis for selected genes in A549, H1299, and H1975 cells. The level of each gene in cancer cell transfected with G9a siRNA is the average ratio of triplicates of two repeated experiments, and is presented as the ratio to control sample transfected with scramble siRNA (* P < 0.05, compared to control cells transfected with scramble siRNA). d Selected gene sets that were enriched upon G9a knockdown in these lung cancer cells

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Molecular Cancer

ISSN: 1476-4598