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Fig. 4 | Molecular Cancer

Fig. 4

From: Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer

Fig. 4

Inhibition of Wnt signaling pathway upon knockdown of G9a in NSCLC cells. Quantitation of TOPFlash luciferase reporter activity in a A549, b H1299, and c H1975 transfected with control or G9a siRNA as indicated (**P < 0.01, compared to control siRNA). Double-label fluorescent immunohistochemistry of cells as indicated at 72 h post-transfection with G9a or control siRNA in d A549, e H1299, and f H1975 cells. Blue is for DAPI nuclear stain, and green is for β–catenin stain

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