Fig. 1

Current and promising therapeutics that can be employed for personalized medicine development: Clinically, ATC therapeutic regime involves use of more than one modality shown above (current therapies, depicted in grey color). Several promising categories of drugs were explored for their therapeutic implications and can be employed in single or combination with other drugs (depicted in green color). However, the best strategy would be to evaluate and design the personalized treatment plan by determining underlying mutations, genetic lesions, oncogenic signaling cascades and other metabolomic “Achilles heels”