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Table 1 Docking scores and binding free energy estimation with all 14–3-3 family members

From: Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer

Protein Drug MMGBSA ΔG Bind
SFN Docetaxel −50.995
SFN BV02 −47.767
SFN BV02_9 −37.437
SFN Enzalutamide −35.406
SFN Corannulene −27.451
SFN MK2206 −25.558
YHWAQ Docetaxel −49.609
YHWAQ MK2206 −44.319
YHWAQ BV02 −41.003
YHWAQ Enzalutamide −36.277
YHWAQ BV02_9 −28.979
YHWAQ Corannulene −26.181
YWHAB Docetaxel −44.997
YWHAB MK2206 −35.065
YWHAB Enzalutamide −33.543
YWHAB BV02 −26.734
YWHAB BV02_9 −25.072
YWHAB Corannulene −21.792
YWHAE Docetaxel −60.766
YWHAE BV02 −52.966
YWHAE MK2206 −44.228
YWHAE Enzalutamide −44.112
YWHAE BV02_9 −39.695
YWHAE Corannulene −17.976
YWHAG Docetaxel −61.867
YWHAG Enzalutamide −40.822
YWHAG MK2206 −37.603
YWHAG BV02_9 −35.213
YWHAG BV02 −32.296
YWHAG Corannulene −25.861
YWHAH Docetaxel −53.17
YWHAH BV02 −52.878
YWHAH BV02_9 −35.691
YWHAH Corannulene −29.735
YWHAH MK2206 −28.84
YWHAH Enzalutamide −26.734
YWHAZ Docetaxel −62.634
YWHAZ BV02 −43.919
YWHAZ Enzalutamide −39.064
YWHAZ BV02_9 −37.594
YWHAZ MK2206 −32.715
YWHAZ Corannulene −23.241