Fig. 8

Knockdown of G3BP2 abolishes the oncogenic effects induced by downregulation of circFNDC3B. T24 or UMUC-3 cells were transfected with si-NC + sh-vector, si-NC + sh-circFNDC3B, si-G3BP2 + sh-circFNDC3B or si-G3BP2 + sh-vector. a and b The cell proliferation was measured by MTS assays. c and d The migratory ability was assessed by wound healing assays. e and f The invasive capacity was evaluated by transwell Matrigel invasion assays. g and h The G3BP2, p-SRC and p-FAK protein levels were detected by western blot assays. Data are presented as the means±SEM of three experiments. *P < 0.05, **P < 0.01, ***P < 0.001 (Student’s t-test). Scale bar, 200 μm