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Fig. 7 | Molecular Cancer

Fig. 7

From: EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis

Fig. 7

circMMP9 enhances GBM growth in vivo. a-b U87 cells were transfected with mock or circMMP9 plasmid. The stable circMMP9 overexpression U87 cells (2 × 106 cells) were injected into nude mice, and tumors were allowed to develop for 7, 14, 21 and 28 days. Representative images of the mice are shown, and the tumor size, volume and weight were determined (***P < 0.001). c CDK4 and AURKA expression was detected via IHC. d-e Stable circMMP9-knockdown U251 cells (2 × 106 cells) were injected into nude mice, and tumors were allowed to grow for 7, 14, 21 and 28 days. Representative images of the mice are shown, and the tumor size, volume and weight were determined (***P < 0.001). f CDK4 and AURKA expression was detected via IHC

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Molecular Cancer

ISSN: 1476-4598