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Table 1 Validation of the EphA2 and EphB2 signatures in GEO and TCGA-COAD public databases

From: EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers

a.

 

GSE35982

FC (P value)

GSE35834

FC (P value)

TCGA-COAD

FC (P value)

GSE4183

Adenoma

FC (P value)

Carcinoma

FC (P value)

IBD

FC (P value)

EPHA2

-1.16

(0.35)

1.18

(0.02)

1.27

(0.40)

1.7

(0.07)

1.67

(0.08)

2.16

(0.003)

miR-423-5p

-2.2

(0.30)

-1.26

(0.09)

-8.82

(2.35e-142)

-

-

-

ARPC1A

-1.07

(0.20)

1.12

(0.17)

-1.09

(0.35)

1.14

(0.32)

1.16

(0.24)

-1.13

(0.39)

PAK1

-1.01

(0.94)

-1.07

(0.25)

-1.21

(0.01)

-1.27

(0.02)

-1.49

(0.0006)

-1.63

(7.42e-05)

GNG12

1.11

(0.46)

-1.63

(2.48e-08)

-1

(0.128)

-1.44

(0.005)

-1.28

(0.04)

-1.35

(0.02)

CREB1

-1.06

(0.40)

-1.04

(0.38)

2.72

(2.85e-34)

1.16

(0.15)

1.36

(0.005)

1.26

(0.04)

ADAMTS14

-1.03

(0.67)

1.03

(0.52)

2.81

(0.0003)

-1.05

(0.85)

1.32

(0.21)

1.52

(0.05)

EPHB2

1.19

(0.49)

1.33

(0.0008)

1.75

(0.03)

3.39

(7.75e-06)

1.26

(0.16)

-1.13

(0.67)

miR-31-5p

49.65

(0.02)

3.17

(0.03)

2.71

(0.41)

-

-

-

miR-31-3p

14.73

(0.005)

-

-

-

-

-

RHOA

1.10

(0.08)

-1.01

(0.71)

-1.08

(0.28)

1.12

(0.06)

-1.29

(0.21)

1.09

(0.13)

CRKL

1.07

(0.54)

1.12

(0.002)

1.18

(0.03)

1.20

(0.139)

1.13

(0.14)

-1.19

(0.22)

CRK

-1.11

(0.36)

-1.25

(0.0008)

-1.12

(0.10)

-1.22

(0.02)

-1.15

(0.09)

-1.13

(0.12)

ITGA5

1.78

(0.30)

-1.08

(0.38)

-1.13

(0.64)

1.88

(0.59)

4.50

(0.03)

4.56

(0.03)

CXCL12

-1.19

(0.69)

-2.40

(9.44e-14)

-3.00

(6.55e-18)

-6.91

(9.80E-09)

-2.90

(2.95E-06)

-1.48

(0.01)

ARPC5

-1.18

(0.05)

1.01

(0.62)

1.09

(0.36)

-1.33

(0.06)

-1.36

(0.05)

-1.37

(0.05)

RASA1

-1.03

(0.61)

1.19

(0.04)

2.60

(1.92e-20)

1.21

(0.02)

1.11

(0.23)

-1.10

(0.30)

SRC

1.23

(0.16)

1.20

(0.0008)

-1.37

(0.02)

-1.37

(0.10)

-1.57

(0.03)

1.79

(0.03)

b.

Multivariate analysis of EPHA2 genetic signature without hsa-miR-423-5p

 

Relative Risk

95% CI

P value

TCGA-COAD (OS)

 ADAMTS14

1.07

0.97 to 1.19

0.17

 CREB1

0.97

0.87 to 1.09

0.65

GSE33113 (MR3)

 ADAMTS14

1.03

0.99 to 1.06

0.05

 CREB1

1.01

0.99 to 1.03

0.44

GSE14333 (DFS)

 ADAMTS14

0.76

0.65 to 0.90

0.001

 CREB1

0.99

0.54 to 1.84

0.99

GSE17536 (OS)

 ADAMTS14

0.79

0.26 to 2.45

0.69

 CREB1

1.43

0.59 to 3.48

0.44

GSE29623 (OS)

 ADAMTS14

0.36

0.04 to 3.06

0.36

 CREB1

0.82

0.13 to 5.1

0.83

Multivariate analysis of EPHB2 genetic signature without hsa-miR-31-5p

 

Relative Risk

95% CI

P value

TCGA-COAD (OS)

 CRK

0.97

0.94 to 1.01

0.15

 CXCL12

1.03

0.99 to 1.07

0.17

 ARPC5

0.99

0.96 to 1.02

0.53

 SRC

1.00

0.97 to 1.02

0.79

GSE33113 (MR3)

 CRK

1.01

1.00 to 1.01

0.01

 CXCL12

1.00

1.00 to 1.00

0.02

 ARPC5

1.00

1.00 to 1.01

0.05

 SRC

1.00

0.95 to 1.05

0.95

GSE14333 (DFS)

 CRK

0.80

0.54 to 1.20

0.29

 CXCL12

0.74

0.60 to 0.92

0.01

 ARPC5

0.81

0.50 to 1.30

0.38

 SRC

1.08

0.79 to 1.48

0.63

GSE17536 (OS)

 CRK

1.14

0.49 to 2.66

0.75

 CXCL12

0.98

0.69 to 1.39

0.90

 ARPC5

1.27

0.37 to 4.35

0.70

 SRC

0.10

0.02 to 0.54

0.01

GSE29623 (OS)

 CRK

0.83

0.15 to 4.52

0.83

 CXCL12

1.02

0.45 to 2.32

0.96

 ARPC5

0.25

0.03 to 2.03

0.19

 SRC

0.09

0.002 to 4.13

0.22

Multivariate analysis of EPHA2 genetic signature with hsa-miR-423-5p

 

Relative Risk

95% CI

P value

TCGA-COAD (OS)

 ADAMTS14

1.07

0.97 to 1.18

0.18

 CREB1

0.98

0.87 to 1.1009

0.67

 hsa-miR-423-5p

1.00

0.99 to 1.00

0.69

GSE 29623 (OS)

 ADAMTS14

0.35

0.04 to 3.02

0.34

 CREB1

0.82

0.13 to 5.12

0.83

 hsa-miR-423-5p

1.04

0.71 to 1.52

0.85

Multivariate analysis of EPHB2 genetic signature with hsa-miR-31-5p

 

Relative Risk

95% CI

P value

TCGA-COAD (OS)

 CRK

0.97

0.93 to 1.01

0.11

 CXCL12

1.03

0.99 to 1.07

0.10

 ARPC5

0.99

0.97 to 1.02

0.65

 SRC

1.00

0.98 to 1.03

0.90

 hsa-miR-31-5p

1.00

1.00 to 1.01

0.001

GSE29623 (OS)

 CRK

0.69

0.12 to 3.81

0.67

 CXCL12

1.31

0.53 to 3.21

0.56

 ARPC5

0.28

0.04 to 2.23

0.23

 SRC

0.12

0.003 to 4.88

0.26

 hsa-miR-31-5p

1.17

0.95 to 1.46

0.14

  1. Validation of the EphA2 and EphB2 signatures in GEO and TCGA-COAD public databases; Fold Change data of miR-423-5p and miRs-31 coherent target genes (miRNA and target gene expression levels are inversely correlated) with significant P values (P < 0.05) are indicated in bold (a). Multivariate Cox proportional hazards regression analysis of EPHA2 and EPHB2 genetic signatures; significant P values (P < 0.05) are indicated in bold (b)
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Molecular Cancer

ISSN: 1476-4598