Fig. 1

a Schematic representation of BRD4 function in the organization and assembly of SE. Binding to hyperacetylated chromatin regions, BRD4 recruits the Mediator complex promoting the assembly of a large platform of transcription regulating proteins, that forms a bridge between SE and Promoter, favoring and stabilizing the binding of RNA-PolII. BRD4 also interacts and activates P-TEFb stimulating transition of RNA-PolII into active elongation. b Effect BETi on SE organization. BETi compete with acetylated residues for the binding at the BRD4 bromodomains releasing BRD4 from chromatin and disassembling the interaction between SE and promoter, reducing RNA-PolII throughput and blocking transcription of key oncogenes