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Fig. 2 | Molecular Cancer

Fig. 2

From: LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression

Fig. 2

MIR31HG knockdown suppressed HNSCC cells proliferation in vitro and vivo. a qRT-PCR analysis of MIR31HG gene expression in FaDu and Cal-27 cells. b MTT assay of cell proliferation in MIR31HG knockdown or NC (transfected with negative control lentivirus) and MOCK (blank control) groups at indicated times. c qRT-PCR analysis of MIR31HG gene expression after MIR31HG overexpression (OE) lentivirus transfected in Cal-27 cells. d MTT assay of cell proliferation in MIR31HG OE or NC groups at indicated times. e The weights of the tumor in nude mice were calculated and compared. f The volumes of tumor in nude mice were calculated and compared. g Tumor images after all the mice were killed and tumors were removed. h Representative images of HE staining, immunohistochemical staining of Ki67. The results are presented as the mean ± SD for each group (n = 5). *P < 0.05, **P < 0.01, ****P < 0.0001 by Student’s t-test

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Molecular Cancer

ISSN: 1476-4598