Fig. 1From: Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosisTumor microenvironment in pancreatic cancer: Formation and expansion of tumor mass confined by the altered basement membrane and stroma causes collapse in blood vessels. In turn, the recruitment of inflammatory and immune cells such as cytokines, macrophages, dendritic cells and growth factors contribute in the remodeling of altered extracellular matrix. These pathological events together contribute to tumor growth, invasion, metastasis and drug resistanceBack to article page