Skip to main content

Table 1 Extracellular matrix components and their functions in pancreatic cancer progression

From: Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

ECM proteins Function Ref
Type 1 collagen Maintain the invasive phenotype of tumor cells; contributes to drug resistance in PDAC cells by increasing the expression of membrane type 1-MMP which potentiates integrin signaling. [128, 129]
Hyaluronan Enhance cell proliferation, metastasis and angiogenesis by interacting with CD44 and receptor for HA-mediated motility (RHAMM) [130, 131]
Fibronectin Promote tumor cell survival through increase ROS; Enhancing tumor cell migration through promoting FAK-dependent activation of Rho [132, 133]
Laminin Promote metastasis through the formation of hemidesmosomes; cleaved laminin stimulates motility of epithelial cells [134]
Cytokeratin Regulate cancer cell growth and motility through modulation of PI3K/Akt signaling [135, 136]
Osteopontin Contribute to chemoresistance towards Gemcitabine treatment via activation of NF-κB pathway [137]
Thrombospondin-1 Facilitate tumor cell motility and metastasis through the up-regulation of matrix metalloprotease 9 [138]
Periostin Promote cell proliferation, migration and invasion of pancreatic cancer cells [139]
Versican Facilitate tumor cell growth and angiogenesis [140]
Tenascin C Enhances tumor cell motility through the activation of integrin signaling [141]