Table 2 Nano-based drug delivery system targeting tumor microenvironment for pancreatic cancer therapy

Gold nanoparticle

Inhibits proliferation and migration of pancreatic cancer cells and pancreatic stellate cells by disrupting the bidirectional communication; inhibit matrix deposition, enhance angiogenesis, and inhibit tumor growth

[142]

GDC-0449 + polymeric prodrug-based nanoparticles

Reduces fibroblast mediated drug resistance; Specifically reduce collagen, α-SMA and glioma-associated protein1 (GLI-1) expression in tumor tissues

[143]

Methacrylate-based Gemcitabine-monomer conjugate

Sustained release of Gemcitabine and enhances cytotoxicity against tumor growth

[144]

3,4-Difluorobenzylidene curcumin + styrene-maleic acid copolymer

Efficient intracellular delivery of 3,4-Difluorobenzylidene curcumin that specifically target tumor microenvironment

[145]

Bisnaphthalimidopropyldi-amino-octane + CH (5)-PAA polymer

Reduces tumor cell proliferation and tumor growth by inducing apoptosis

[146]

Gemcitabine + Hybrid nanoparticle

Systemic and targeted delivery of Gemcitabine to reduce tumor growth

[147]

Hybrid iron oxide-gold nanoparticles

Targeted drug delivery for tumor retardation

[148]

Paclitaxel + nanoemulsion

Enhances chemotherapeutic efficacy of drug by targeted delivery

[149]