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Table 2 Nano-based drug delivery system targeting tumor microenvironment for pancreatic cancer therapy

From: Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

Compound Mechanism of action Ref
Gold nanoparticle Inhibits proliferation and migration of pancreatic cancer cells and pancreatic stellate cells by disrupting the bidirectional communication; inhibit matrix deposition, enhance angiogenesis, and inhibit tumor growth [142]
GDC-0449 + polymeric prodrug-based nanoparticles Reduces fibroblast mediated drug resistance; Specifically reduce collagen, α-SMA and glioma-associated protein1 (GLI-1) expression in tumor tissues [143]
Methacrylate-based Gemcitabine-monomer conjugate Sustained release of Gemcitabine and enhances cytotoxicity against tumor growth [144]
3,4-Difluorobenzylidene curcumin + styrene-maleic acid copolymer Efficient intracellular delivery of 3,4-Difluorobenzylidene curcumin that specifically target tumor microenvironment [145]
Bisnaphthalimidopropyldi-amino-octane + CH (5)-PAA polymer Reduces tumor cell proliferation and tumor growth by inducing apoptosis [146]
Gemcitabine + Hybrid nanoparticle Systemic and targeted delivery of Gemcitabine to reduce tumor growth [147]
Hybrid iron oxide-gold nanoparticles Targeted drug delivery for tumor retardation [148]
Paclitaxel + nanoemulsion Enhances chemotherapeutic efficacy of drug by targeted delivery [149]