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Fig. 2 | Molecular Cancer

Fig. 2

From: Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Fig. 2

Overexpression of PLCE1 is relevant with the angiogenesis and proliferation of ESCC. a Representative IHC images of PLCE1, CD34 and Ki-67 staining (200×) in ESCC and normal esophageal tissue specimens. b The score of PLCE1 and Ki-67 and the MVD in ESCC were higher than normal esophageal tissues. Each bar represents the mean ± SD for triplicate experiments. c, d The correlation analysis between PLCE1 with MVD and Ki-67 were carried out. PLCE1 and MVD are positively correlated, so as PLCE1 and Ki-67. e Representative IHC images of PLCE1, CD34 and Ki-67 staining according to intensities of PLCE1, CD34 and Ki-67 staining in consecutive ESCC tissues. f MVD numbers and Ki-67 score were higher in IHC with positive PLCE1 expression compared to negative c-kit expression. g, h Kaplan-Meier curves for patients. High-MVD (MVD > 40) group (n = 70) and Ki-67-positive (n = 84) had poor prognosis compared with low-MVD expression group (n = 35) and a Ki-67-negative group (n = 34)

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Molecular Cancer

ISSN: 1476-4598