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Fig. 6 | Molecular Cancer

Fig. 6

From: Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Fig. 6

PLCE1 enhances angiogenesis and inhibits apoptosis via activation of the NF-κB signaling pathway in ESCC in vivo. a Xenograft model in nude mice; tumor images from all mice on days 14 and 25. Body weight b, tumor volume growth curves c, d and mean tumor weights e for tumors formed by indicated cells. f Survival, g Expression of p-IκBα (Ser32), Bcl-2, and VEGF-C in nude mouse tissue. h, i H&E and IHC staining and IF confirm PLCE1 induced aggressive phenotype of ESCC cells in vivo, and Bay11–7082 can reverse this. HE: Scale bar, 5 mm; PLCE1, p65, Ki-67, CD34, Scale bar, 100 μm; Bcl-2, Scale bar, 50 μm

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Molecular Cancer

ISSN: 1476-4598