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Fig. 9 | Molecular Cancer

Fig. 9

From: RETRACTED ARTICLE: Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

Fig. 9

High TINCR expression is associated with worse survival and poor response to trastuzumab theray. a ROC curve was established to show the ability of TINCR expression in differentiating responding patients from non-responding patients. b The number of patients with high or low TINCR expression was shown as in responding or non-responding patients. c Overall survival and progressive-free survival of the 60 patients is represented by Kaplan–Meier curves. Expression level of TINCR was categorized into “high” and “low” using the cut-off point (0.138) established by ROC curve. d Correlation of RNA expression between TINCR and HER-2, TINCR and Snail-1, TINCR and miR-125b were analyzed from the TCGA breast cancer dataset by using online database Starbase. e The relationships of the RNA expression between TINCR and HER-2, TINCR and Snail-1, TINCR and miR-125b in breast cancer tissues were analyzed by Spearman’s correlation test. f A scheme of the proposed mechanisms, the H3K27 acetylation-induced TINCR expression sponges miR-125b, thereby promoting trastuzumab resistance via the HER-2 upregulation and then further causing EMT via the Snail-1 upregulation

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