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Fig. 2 | Molecular Cancer

Fig. 2

From: RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers

Fig. 2

a Validation of the circRNAs expression by qRT-PCR. The expressions of top four up-regulated circRNAs in CRC-m samples from RNA-Seq data were evaluated using qRT-PCR in the sample from 32 CRC patients with or without liver metastasis. b, c ROC curve analysis of differentially expressed circRNAs. ROC curve analysis of circRNA_0001178 and circRNA_0000826 in CRC-m patients versus CRC patients. AUC values are given on the graphs. d, e ceRNA analysis for circRNA_0001178 and circRNA_0000826 respectively. The cytoscape software was used to show the circRNA-miRNA-mRNA interactions. Base on the miRNA prediction and bioinformatics analyses, we show the top 5 miRNAs may regulated by circRNA_0001178 (d), circRNA_0000826 (e) and top 5 target genes of each miRNA respectively

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