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Fig. 8 | Molecular Cancer

Fig. 8

From: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression

Fig. 8

circAGFG1 promotes cell proliferation and invasion through circAGFG1/miR-195-5p/CCNE1 axis. a and b The cell proliferation and invasion were determined after transfection with indicated vectors, miRNAs or inhibitors by EdU and transwell assays, respectively (magnification, × 100, scale bar, 100 μm). c Relative protein levels of CCNE1 in cells were assessed by IF after transfection (magnification, × 100, scale bar, 100 μm). d and e Relative expression of CCNE1 and downstream cell cycle-related molecules at protein level in cells transfected with indicated vectors, miRNAs or inhibitors was determined by western blot. f Schematic diagram of how circAGFG1 promotes TNBC tumorigenesis and progression. Data were indicated as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001

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