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Fig. 1 | Molecular Cancer

Fig. 1

From: The novel roles of circRNAs in human cancer

Fig. 1

Biogenesis of circRNAs. Different types of circRNAs are generated via different mechanisms. In lariat-driven circularization, the exon skips along with RNA folding, and exonic circRNAs or EIciRNAs are formed with or without removing introns. In intron-pairing-driven circularization, the formation of exonic circRNAs or EIciRNAs are regulated by base pairing in introns on both sides of pre-mRNA. RBPs bind to the specific sequence of introns, which affect the biogenesis of circRNA. In the formation of intronic circRNAs, the intron lariat is formed with the combination of conserved motifs located at upstream and downstream of introns

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