Table 1 Database about circRNAs

Circbase

http://www.circbase.org/

CircBase merged and unified data sets of circRNAs and the evidence supporting their expression, and also provided scripts to identify known and novel circRNAs in sequencing data

[61]

CIRCpedia v2

http://www.picb.ac.cn/rnomics/circpedia

CIRCpedia contained comprehensive circRNA annotation from over 180 RNA-seq datasets across six different species

[62]

DeepBase v2.0

http://rna.sysu.edu.cn/deepBase/

DeepBase v2.0 annotated 14,867 human circRNAs

[63]

CircRNADb

http://202.195.183.4:8000/circrnadb/circRNADb.php

CircRNADb provided the detailed information of the circRNA, including genomic information, exon splicing, genome sequence, IRES, ORF and references

[64]

Circnet

http://circnet.mbc.nctu.edu.tw/

Circnet generated an integrated regulatory network that illustrated the regulation between circRNAs, miRNAs and genes

[65]

Starbase v2.0

http://starbase.sysu.edu.cn/

StarBase v2.0 systematically identified the RNA-RNA and protein-RNA interaction networks from 108 CLIP-Seq data sets generated by 37 independent studies

[66]

CSCD

http://gb.whu.edu.cn/CSCD/

CSCD predicted the microRNA response element sites, RNA binding protein sites and potential open reading frames for each circRNA

[67]

CircInteractome

http://circinteractome.nia.nih.gov/

CircInteractome searched public circRNA, miRNA, and RBP databases to provide bioinformatic analyses of binding sites on circRNAs and additionally analyzes miRNA and RBP sites on junction and junction-flanking sequences

[68]

CirclncRNAnet

http://app.cgu.edu.tw/circlnc/

CirclncRNAnet provided a “one-stop” resource for in-depth analyses of ncRNA biology

[69]

ExoRBase

http://www.exorbase.org/

ExoRBase provided annotation, expression level and possible original tissues about 58,330 circRNAs in human blood exosomes

[70]

CircRNADisease

http://cgga.org.cn:9091/circRNADisease/

CircRNA Disease provided experimentally supported circRNA and disease associations

[71]