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Table2 A list of circRNAs in tumorigenesis

From: The novel roles of circRNAs in human cancer

Cancer types CircRNA (Circbase ID) Roles in cancer Cancer phenotype Sponge miRNA Target gene Clinical significance Reference
Hepatocellular carcinoma circMTO1 (hsa_circ_0007874) Tumor suppressor Inhibits cell proliferation and invasion and promotes apoptosis miR-9 p21 Overall survival [36]
  cSMARCA5 (hsa_circ_0001445) Tumor suppressor Inhibits cell growth and migration miR-17-3p and miR-181b-5p TIMP3 Aggressive characteristics; overall survival, recurrence-free survival after hepatectomy [72]
  circZKSCAN1 (hsa_circ_0001727) Tumor suppressor Inhibits cell growth, migration and invasion / / Tumor numbers, vascular invasion, tumor grade, cirhosis [73]
Breast cancer circ-Ccnb1 (hsa_circ_0072758) Tumor suppressor Decreases cell proliferation and promote apoptosis / / / [74]
  circGFRA1 (hsa_circ_0005239) Oncogene Promotes cell proliferation and inhibits apoptosis miR-34a GFRA1 Clinical outcomes [75]
  circEPSTI1 (hsa_circ_0000479) Oncogene Promotes cell proliferation and inhibits apoptosis miR-4753 and miR-6809 BCL11A Overall survival [76]
Leukaemia f-circRNA Oncogene Promotes cellular transformation, cell viability and resistance upon therapy / / / [11]
Lung cancer circ0006916 (hsa_circ_0006916) Tumor suppressor Inhibits cell proliferation miR-522-3P PHLPP1 / [77]
  F-circEA Oncogene Promote cell migration and invasion / / Novel biomarker for diagnosis [78]
Glioma circ-FBXW7 Tumor suppressor Inhibited cell proliferationand cell cycle acceleration / / Overall survival [57]
  circ-SHPRH (hsa_circ_0001649) Tumor suppressor Reduced malignant behavior and tumorigenicity / / / [58]
Colorectal cancer circCCDC66 (hsa_circ_0001313) Oncogene Promoted cell proliferation, migration and invasion miR-33b and miR-93 MYC Biomarker for cancer detection and prognosis [79]
  circHIPK3 (hsa_circ_0000284) Oncogene Promoted cell proliferation, migration, invasion, and inhibited apoptosis miR-7 FAK,IGF1R, EGFR, YY1 Metastasis, advanced clinical stage; overall survival [39]
  circITGA7 (hsa_circ_0026782) Tumor suppressor Suppressed cell proliferation and metastasis miR-370-3p NF1 Tumor size, lymph metastasis, distant metastasis; TNM stage [80]
Bladder cancer circHIPK3 (hsa_circ_0000284) Tumor suppressor Inhibited cell migration and invasion miR-558 HPSE / [38]
  circ-ITCH Tumor suppressor Inhibited cell growth, colony formation, migration and invasion miR-17 and miR-224 p21, PTEN / [49]