Table2 A list of circRNAs in tumorigenesis
Cancer types | CircRNA (Circbase ID) | Roles in cancer | Cancer phenotype | Sponge miRNA | Target gene | Clinical significance | Reference |
|---|---|---|---|---|---|---|---|
Hepatocellular carcinoma | circMTO1 (hsa_circ_0007874) | Tumor suppressor | Inhibits cell proliferation and invasion and promotes apoptosis | miR-9 | p21 | Overall survival | [36] |
| Â | cSMARCA5 (hsa_circ_0001445) | Tumor suppressor | Inhibits cell growth and migration | miR-17-3p and miR-181b-5p | TIMP3 | Aggressive characteristics; overall survival, recurrence-free survival after hepatectomy | [72] |
| Â | circZKSCAN1 (hsa_circ_0001727) | Tumor suppressor | Inhibits cell growth, migration and invasion | / | / | Tumor numbers, vascular invasion, tumor grade, cirhosis | [73] |
Breast cancer | circ-Ccnb1 (hsa_circ_0072758) | Tumor suppressor | Decreases cell proliferation and promote apoptosis | / | / | / | [74] |
| Â | circGFRA1 (hsa_circ_0005239) | Oncogene | Promotes cell proliferation and inhibits apoptosis | miR-34a | GFRA1 | Clinical outcomes | [75] |
| Â | circEPSTI1 (hsa_circ_0000479) | Oncogene | Promotes cell proliferation and inhibits apoptosis | miR-4753 and miR-6809 | BCL11A | Overall survival | [76] |
Leukaemia | f-circRNA | Oncogene | Promotes cellular transformation, cell viability and resistance upon therapy | / | / | / | [11] |
Lung cancer | circ0006916 (hsa_circ_0006916) | Tumor suppressor | Inhibits cell proliferation | miR-522-3P | PHLPP1 | / | [77] |
| Â | F-circEA | Oncogene | Promote cell migration and invasion | / | / | Novel biomarker for diagnosis | [78] |
Glioma | circ-FBXW7 | Tumor suppressor | Inhibited cell proliferationand cell cycle acceleration | / | / | Overall survival | [57] |
| Â | circ-SHPRH (hsa_circ_0001649) | Tumor suppressor | Reduced malignant behavior and tumorigenicity | / | / | / | [58] |
Colorectal cancer | circCCDC66 (hsa_circ_0001313) | Oncogene | Promoted cell proliferation, migration and invasion | miR-33b and miR-93 | MYC | Biomarker for cancer detection and prognosis | [79] |
| Â | circHIPK3 (hsa_circ_0000284) | Oncogene | Promoted cell proliferation, migration, invasion, and inhibited apoptosis | miR-7 | FAK,IGF1R, EGFR, YY1 | Metastasis, advanced clinical stage; overall survival | [39] |
| Â | circITGA7 (hsa_circ_0026782) | Tumor suppressor | Suppressed cell proliferation and metastasis | miR-370-3p | NF1 | Tumor size, lymph metastasis, distant metastasis; TNM stage | [80] |
Bladder cancer | circHIPK3 (hsa_circ_0000284) | Tumor suppressor | Inhibited cell migration and invasion | miR-558 | HPSE | / | [38] |
| Â | circ-ITCH | Tumor suppressor | Inhibited cell growth, colony formation, migration and invasion | miR-17 and miR-224 | p21, PTEN | / | [49] |