Fig. 1

CircRNA expression profiles in gastric cancer tissues and paired normal gastric tissues. a. The length of most circRNAs was less than 1000 nucleotides. b. We analysed circRNA composition in terms of gene distribution. c. A cluster heat map was used to show the expression variations of these circRNA transcripts in cancerous tissues relative to matched normal tissues. d. Volcano plots illustrated that among differentially expressed circRNAs, 33 were upregulated and 16 were downregulated in GC tissues relative to normal tissues. e. We detected higher circNRIP1 expression in 80 GC samples relative to adjacent normal samples via qRT-PCR. f. We confirmed the higher levels of circNRIP1 in the SGC-7901, BGC-823, MGC-803, AGS, MKN-45 and HGC-27 GC cell lines relative to GES-1 cells. All data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001