Fig. 3
From: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis
Hsa_circ_0001946 overexpression affects the proliferation, migration, and invasion of Eca109. (a) ESCC cell lines (Eca109, TE-1, K30, and K50) were transfected with lentivirus and the expressions of hsa_circ_0001946 were elevated a lot by qRT-PCR. (b) MTT method showed that hsa_circ_0001946 overexpression inhibited Eca109 proliferation after 48 h. (c) Wound-healing assay indicated that hsa_circ_0001946 overexpression decreased Eca109 migration after 24 h. (d) Transwell assays showed that hsa_circ_0001946 overexpression decreased Eca109 migration and invasion after 48 h incubation. (n = 3; Student’s t-test was used for significance test and data were presented as the means± SEM). (E) Subcutaneous xenografts excised from nude mice. (n = 6;Student’s t-test was used for significance test and data were presented as the means± SEM)