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Table 2 Integrins expressed on leukocytes and tumor cells and their ligands

From: The functional role of integrins during intra- and extravasation within the metastatic cascade

Adhesion molecule

Family

Leukocyte subtype

Ligand

Expression on tumor cells

VLA-4 (α4ß1)

(CD49d)

Integrin

Monocytes

Neutrophils in case of sepsis

VCAM-1

MAdCAM-1

JAM-B

Melanoma, osteosarcoma, kidney carcinoma, leukemia, oral squamous cell carcinoma, ovarian cancer

LFA-1 (αLß2)

(CD11a/CD18)

Integrin

Neutrophils

Monocytes

ICAM-1

ICAM-2

JAM-A

 

Gp150,95

(CD11c/CD18)

Integrin

Monocytes

Macrophages

Granulocytes

Langerhans cells

iC3b

JAM-C

 

α4ß7

(CD49d/ß7)

Integrin

Lymphocytes (mucosal lymphoid nodules)

MAdCAM-1

 

αMß2 (mac-1)

(CD11b/CD18)

Integrin

Monocytes

Macrophages

Granulocytes

Langerhans cells

iC3b

ICAM-1

ICAM-2

JAM-C

 

αDß2

Integrin

Macrophages ?

ICAM-3

 

CD47

 

T cell

VCAM-1

ICAM-1

 

ICAM-1

Ig superfamily

Monocytes

Epithelial cells

Fibroblasts

LFA-1 (leukocytes)

Mac-1 (leukocytes)*

Breast cancer, melanoma, oral squamous carcinoma, esophageal squamous carcinoma, papillary thyroid carcinoma, salivary adenoid cystic carcinoma, gastric cancer, non-small-cell lung cancer, osteosarcoma, prostate cancer

ICAM-2

ICAM-3

Ig superfamily

Endothelial cells

Leukocytes

Langerhans cells

LFA-1 (CD11a)

 

VCAM-1

Ig superfamily

Activated endothelial cells

VLA-4

 

PECAM-1

Ig superfamily

Endothelial cells

Monocytes

Neutrophils

PECAM-1 (CD31)

 

MAdCAM-1

Ig superfamily

Endothelial cells

L-selectin

α4ß7

 

L1-CAM

Ig superfamily

Tumor cells

L1-CAM

α5ß1

αVß3 (endothelium)

Colorectal carcinoma, epithelial ovarian carcinoma, renal cell carcinoma, melanoma, pancreatic ductal adenocarcinoma, breast cancer

αVß3

Integrin

Tumor cells

L1-CAM

Prostate cancer, melanoma

α5ß1

Integrin

Tumor cells

L1-CAM

Breast cancer

  1. CAMs in bold, have been identified on tumor cells (for references see text and table 1). *Leukocytes act as a bridge between tumor cell and the endothelium