From: The functional role of integrins during intra- and extravasation within the metastatic cascade
Adhesion molecule | Family | Leukocyte subtype | Ligand | Expression on tumor cells |
---|---|---|---|---|
VLA-4 (α4ß1) (CD49d) | Integrin | Monocytes Neutrophils in case of sepsis | VCAM-1 MAdCAM-1 JAM-B | Melanoma, osteosarcoma, kidney carcinoma, leukemia, oral squamous cell carcinoma, ovarian cancer |
LFA-1 (αLß2) (CD11a/CD18) | Integrin | Neutrophils Monocytes | ICAM-1 ICAM-2 JAM-A |  |
Gp150,95 (CD11c/CD18) | Integrin | Monocytes Macrophages Granulocytes Langerhans cells | iC3b JAM-C | Â |
α4ß7 (CD49d/ß7) | Integrin | Lymphocytes (mucosal lymphoid nodules) | MAdCAM-1 |  |
αMß2 (mac-1) (CD11b/CD18) | Integrin | Monocytes Macrophages Granulocytes Langerhans cells | iC3b ICAM-1 ICAM-2 JAM-C |  |
αDß2 | Integrin | Macrophages ? | ICAM-3 |  |
CD47 | Â | T cell | VCAM-1 ICAM-1 | Â |
ICAM-1 | Ig superfamily | Monocytes Epithelial cells Fibroblasts | LFA-1 (leukocytes) Mac-1 (leukocytes)* | Breast cancer, melanoma, oral squamous carcinoma, esophageal squamous carcinoma, papillary thyroid carcinoma, salivary adenoid cystic carcinoma, gastric cancer, non-small-cell lung cancer, osteosarcoma, prostate cancer |
ICAM-2 ICAM-3 | Ig superfamily | Endothelial cells Leukocytes Langerhans cells | LFA-1 (CD11a) | Â |
VCAM-1 | Ig superfamily | Activated endothelial cells | VLA-4 | Â |
PECAM-1 | Ig superfamily | Endothelial cells Monocytes Neutrophils | PECAM-1 (CD31) | Â |
MAdCAM-1 | Ig superfamily | Endothelial cells | L-selectin α4ß7 |  |
L1-CAM | Ig superfamily | Tumor cells | L1-CAM α5ß1 αVß3 (endothelium) | Colorectal carcinoma, epithelial ovarian carcinoma, renal cell carcinoma, melanoma, pancreatic ductal adenocarcinoma, breast cancer |
αVß3 | Integrin | Tumor cells | L1-CAM | Prostate cancer, melanoma |
α5ß1 | Integrin | Tumor cells | L1-CAM | Breast cancer |