The functional role of integrins during intra- and extravasation within the metastatic cascade

Table 4 Alternative adhesion molecules

Leukocyte Adhesion Molecule	Alternative Adhesion Molecule	Ligand
VLA-4 (α4ß1)	α4ß7 α9ß1 αDß2	VCAM-1
VLA-4 (α4ß1)	α4ß7	MAdCAM-1
α4ß7	α4ß1	MAdCAM-1
LFA-1 (αLß2)	αXß2 αMß2 αDß2	ICAM
Gp150,95	αXß2 αMß2	iC3b
L1-CAM	αVß1^a αIIBß3^a	α5ß1 αVß3

^aαVß1 and αIIBß3 as possible alternative adhesion molecules bind to L1-CAM and therefore could only be of use for tumor cells to bind to leukocytes mediating adhesion to the endothelium as linker cells
The table shows alternative adhesion molecules (Humphries et al. 2006) tumor cells could use instead of the adhesion molecules present on leukocytes to adhere to the vascular endothelium for extravasation

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