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Fig. 5 | Molecular Cancer

Fig. 5

From: PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA

Fig. 5

piR-36,712 inhibits SEPW1 expression and functions by interaction with SEPW1P RNA. a Levels of SEPW1 mRNA in MCF7 and ZR75–1 cells with stable overexpression (OE) or knockdown (KD) of piR-36,712 (mean ± SEM; **, P < 0.001; ***, P < 0.0001). b MS2-RIP and qRT-PCR analysis shows interaction of piR-36,712 with SEPW1 mRNA. c, d Effects of OE or KD of SEPW1P or SEPW1 on breast cancer cell proliferation induced by OE or KD of piR-36,712 (mean ± SEM; ***, P < 0.001). e, f Effects of OE or KD of SEPW1P or SEPW1 on breast cancer cell cycle progression induced by OE or KD of piR-36,712. g, h Effects of OE or KD of SEPW1P or SEPW1 on breast cancer cell migration and invasion induced by OE or KD of piR-36,712 (mean ± SEM; *, P < 0.05; **, P < 0.01 and ***, P < 0.001)

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Molecular Cancer

ISSN: 1476-4598