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Fig. 6 | Molecular Cancer

Fig. 6

From: PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA

Fig. 6

piR-36,712 suppresses the malignant phenotypes of breast cancer cells via P53. a Effects of piR-36,712 on expressions of SEPW1 and its downstream P53, P21, Slug and E-cadherin in MCF7 and ZR75–1 cells. b Inhibitory effect of PFT-α on expression of P53 and its downstream in MCF7 and ZR75–1 cells overexpressing piR-36,712. c Suppression of P53 by PFT-α inhibits the inhibitory effect of piR-36,712 on proliferation of MCF7 and ZR75–1 cells. d Suppression of P53 by PFT-α suppresses the inhibitory effect of piR-36,712 on colony formation ability of MCF7 and ZR75–1 cells. e Suppression of P53 by PFT-α inhibits the effect of piR-36,712 on G1 phase cell cycle arrest in MCF7 and ZR75–1 cells. f Suppression of P53 by PFT-α inhibits the inhibitory effect of piR-36,712 on MCF7 and ZR75–1 cell migration and invasion

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Molecular Cancer

ISSN: 1476-4598