Fig. 7

Effects of piR-36,712 on the chemosensitivity of breast cancer cells to paclitaxel (PTX) or doxorubicin (DOX). a, b Effect of overexpression (OE) or knockdown (KD) of piR-36,712 on sensitivity of MCF7 and ZR75–1 cells to PTX or DOX in vitro. c-f OE of piR-36,712 increased but KD of piR-36,712 decreased the sensitivity of breast cancer xenografts in mice to PTX or DOX. Shown are mean ± SEM (N = 5); *, P < 0.05; **, P < 0.01, ***, P < 0.001. g, h Inhibitory effect of intra-tumor administration of agopiR-36,712 on xenograft growth. Shown are pictures of tumors with or without injection of agopiR-36,712 (left panel) and the growth curves of tumors (right panel). Each point in the curves presents mean ± SEM (N = 5). *, P < 0.05; **, P < 0.01, ***, P < 0.001