Table 2 The application of autophagy inhibitors in tumor therapy
Autophagy Inhibitors | Tumor Types | Autophagy-Modulating Mechanism | Research Types |
|---|---|---|---|
Quercetin | Cervical cancer | Inhibit LC-3 and beclin-1 activation [188] | Preclinical |
Chloroquine | Bladder cancer | Prohibit lysosomal functions and autophagy [189] | Preclinical |
SB202190 | Colorectal Cancer | Cause cell cycle arrest and autophagic cell death [190] | Preclinical |
Elaiophylin | Ovarian cancer | Block autophagic flux by attenuating lysosomal cathepsin activity [191] | Preclinical |
Peiminine | Glioblastoma | Inhibit autophagy by inhibiting AMPK-ULK1 pathways [192] | Preclinical |
U0126 | Pancreatic Cancer | Induce apoptosis after autophagy inhibition [193] | Preclinical |