Skip to main content

Table 1 Association between ITGBL1 expression and clinicopathological factors

From: Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer

Variables Testing cohort N (%) Validation cohort N (%)
ITGBL1 level   ITGBL1 level  
Low High P value Low High P value
N=130 N=71   N=256 N=212  
Gender
 Male 61 29 0.41 162 113 0.03
 Female 69 42   94 99  
Age
 <65 80 45 0.88 114 81 0.19
 ≥65 50 26   142 131  
Location
 Colon 65 36 0.92 160 131 0.88
 Rectum 65 35   96 81  
Histology
 Differentiated 119 68 0.39 239 191 0.23
 Undifferentiated 11 3   17 21  
Tumor size (mm)
 ≤45 81 29 <0.01 151 72 <0.0001
 >45 49 42   91 137  
Unavailable 0 0   14 3  
T stage
 T1,T2 37 7 <0.01 68 24 <0.0001
 T3,T4 93 64   188 188  
Lymphovascular invasion
 Absent 55 11 <0.0001 41 16 <0.01
 Present 75 60   213 196  
Unavailable 0 0   2 0  
Lymph node Metastasis
 Absent 69 21 0.001 137 113 0.96
 Present 61 50   119 99  
Distant metastasis
 Absent 120 57 0.02 224 163 <0.01
 Present 10 14   32 49  
Stage
 I, II 67 18 <0.001 132 103 0.52
 III, IV 63 53   124 109  
Preoperative CEA (ng/ml)
 <5 88 39 0.07 156 114 0.12
 5≤ 42 32   100 98