Fig. 1

PVT1 is significantly upregulated in GBC tissues and cell lines. (a) PVT1 expression levels in GBC tissues and paired non-tumor tissues of the GEO database (GSE76633). (b) PVT1 was upregulated in GBC tissues detected by qPCR in 20 pairs of GBC tissues. (c) Representative PVT1 staining patterns. Scale bar, 100 μm. (d-e) The expression level of PVT1 was higher in GBC tissues than adjacent normal tissues. Scale bar, 100 μm. High PVT1 expression correlated with advanced TNM stage and distant metastasis. (f) High PVT1 expression was significantly associated with poor OS in GBC patients. *P < 0.05, **P < 0.01, ***P < 0.001. Error bars indicate mean ± SD