Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

Table 2 Univariate and multivariate analyses of overall survival of gallbladder cancer

	Clinicopathological parameters	Overall survival (OS)
	Clinicopathological parameters	HR	95%(CI)	P value
Univariate analyses	Age (>median vs. ≤median)	1.102	0.607–1.998	0.750
	Gender (male vs. female)	1.289	0.663–2.507	0.454
	Tumor size (> 5 cm vs. ≤5 cm)	1.199	0.664–2.168	0.547
	TNM stage (III-IV vs. I-II)	4.525	2.296–8.919	< 0.001**
	Distant metastasis (Present vs. Absent)	2.894	1.448–5.783	0.003**
	PVT1 expression (High vs. Low)	2.467	1.338–4.548	0.004**
	HK2 expression (High vs. Low)	2.220	1.246–3.953	0.007**
Multivariate analyses	TNM stage (III-IV vs. I-II)	4.119	2.061–8.232	< 0.001**
	Distant metastasis (Present vs. Absent)	2.059	1.010–4.196	0.047**
	PVT1 expression (High vs. Low)	1.986	1.055–3.739	0.033**
Multivariate analyses	TNM stage (III-IV vs. I-II)	2.444	1.267–4.714	0.008**
	Distant metastasis (Present vs. Absent)	1.936	1.024–3.469	0.041**
	HK2 expression (High vs. Low)	1.842	1.103–3.351	0.045**

Abbreviations: TNM = tumor-node-metastasis; HR = hazard ratio; CI = confidential interval; PVT1 = plasmacytoma variant translocation 1; HK2 = Hexokinase 2; **P < .05

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