Fig. 3From: Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasisLOXL4 promotes HCC migration and invasion in vitro and metastasis in vivo. a-b. Cell migration (a) and invasion (b) potential was determined in SK-Hep1 and SMMC-7721 cells transfected with LOXL4 or control vector according to Transwell assays. c-d. Cell migration (c) and invasion (d) potential was determined in Hep3B and Huh7 cells transfected with shLOXL4 or shcontrol according to Transwell assays. e Tumor number on the liver surface 6 weeks after LOXL4-overexpressing SK-Hep1 cells (LOXL4/SK-Hep1) and control cells (vector/SK-Hep1) were orthotopically inoculated into the left hepatic lobe of nude mice. f Representative photographs of hematoxylin and eosin (H&E) staining in liver tissues from mice orthotopically inoculated with LOXL4/SK-Hep1 and control cells. g Lung metastases 6 weeks after LOXL4/SK-Hep1 and control cells were intravenously injected into nude mice detected by H&E staining. (** P < 0.01) (Scale bar: a-d 100 μm, f-g 200 μm)Back to article page