Fig. 6
From: Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis
Secreted LOXL4 but not rhLOXL4 promotes HCC migration. a Examination of LOXL4 protein in the CM derived from LOXL4-overexpressing cells (CM/LOXL4) and control cells (CM/vector) by western blotting. b Cell migration potential was determined in parental SK-Hep1 and SMMC-7721 cells incubated with CM/LOXL4 and CM/vector according to Transwell assays. c Identification of rhLOXL4 secreted by human embryonic kidney 293/Epstein-Barr nuclear antigen cells by western blotting with an antibody against LOXL4. d Cell migration potential was determined in SK-Hep1 and SMMC-7721 cells upon treatment with vehicle or different concentrations of rhLOXL4 according to Transwell assays. (Scale bar: b and d 100 μm). (** P < 0.01)