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Fig. 6 | Molecular Cancer

Fig. 6

From: Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma

Fig. 6

TLR7-NFκB signaling pathway activation is responsible for FMR1-AS1-mediated cancer stem cell transition. a, b NFκB activities and c-Myc level of ESCC cells with TLR7 knockdown after 48 h incubation with indicated exosomes, examined by EMSA and western blotting. c Subcutaneous xenograft assay of TLR7-downregulated and respective control ESCC cells in nude mice with intratumoral injection of indicated exosomes (n = 5 per group). d, e NFκB activities and c-Myc level of ESCC cells with MyD88 knockdown after 48 h incubation with indicated exosomes, examined by EMSA and western blotting. f Subcutaneous xenograft assay of MyD88-downregulated and respective control ESCC cells in nude mice with intratumoral injection of indicated exosomes (n = 5 per group). g Subcutaneous xenograft assay co-injected with cell mixture of ECA-109_Luc and ECA-109_FMR1-AS1/ECA-109_Control cells (1:5), KYSE-150_Luc and KYS-150_FMR1-AS1/KYSE-150_Control cells (1:5)

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Molecular Cancer

ISSN: 1476-4598