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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression

Fig. 5

TFRC induces bladder cancer cell proliferation, migration and invasion. a qPCR analysis of TFRC expression in different BC cell lines. b, c cTFRC level correlated with TFRC mRNA expression in BC cell lines (b) and BC clinical samples (c). d TFRC was silenced in EJ and T24 BC cell lines by shRNAs and the TFRC-silenced stable cell lines were established. e Proliferation of EJ and T24 cells transfected with the above TFRC shRNA assessed using 3H-TdR incorporation at the indicated days. f-h TFRC depletion causes a diminished attachment (f), migration (g) and invasion (h) capacity in three BC patients’ primary cells. i TFRC-silenced EJ and T24 cells were subcutaneously injected into BALB/c nude mice for observation of tumor growth. Results are shown as mean ± SD. n = 12 for each group. Data are shown as mean ± SD. **P < 0.01 by two-tailed Student’s t test. Data represent at least three independent experiments

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