Fig. 9
From: Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression
The schematic diagram shows the mechanism underlying cTFRC as a ceRNA for miR-107. Activation of the EMT signaling pathway in bladder cancer patients promotes transcriptional activation of TFRC, and expression of TFRC and cTFRC is increased in bladder cancer cells. On the one hand, TFRC can promote the degradation of E-cadherin, forming positive feedback to promote EMT, and ultimately promote cell invasion and migration. On the other hand, TFRC acts as a receptor to initiate multiple signaling pathways that promote downstream cell proliferation. In terms of mechanism, as shown by the dotted oval box, cTFRC upregulating the expression of TFRC by absorbs miRNA-107 targeting TFRC, thereby promoting epithellal-mesenchymal transition, cell proliferation and cell invasion in bladder carcinoma