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Fig. 5 | Molecular Cancer

Fig. 5

From: Natural killer group 2D receptor and its ligands in cancer immune escape

Fig. 5

Effects of virus on NKG2DL expression. 1) HBV infection promoted the expression of GATA-2 and GATA-3 and directly bound to the promoter region of MICA/B to inhibit MICA/B expression. 2) Viral miRNA targeting mRNA reduced MICB translation. 3) E3/19 K protein increased the synthesis of the NKG2D ligands MICA and MICB and stored them in the immature form in the endoplasmic reticulum but inhibited their expression on the cell surface. 4) HIV-1 caused infected cells to release soluble ligands (sNKG2DL)

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